Chromatin Architecture
The three-dimensional organisation of DNA, histones and regulatory complexes that helps control genome activity inside the nucleus.
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mRNA Therapeutics
Medicines that deliver engineered messenger RNA so cells transiently produce a therapeutic protein or antigen.
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Autophagy
Cellular pathways that deliver cytoplasmic material to lysosomes or vacuoles for degradation, quality control and recycling.
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Spatial Transcriptomics
Methods that measure gene expression while preserving the locations and neighbourhoods of cells within tissue.
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Gene Regulatory Networks
Interacting genes, regulatory DNA and molecular factors that control when and where biological programmes are expressed.
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Ribosome Translation
The molecular decoding of messenger RNA into an ordered amino-acid chain by ribosomes and transfer RNAs.
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Synthetic Biology
The design and construction of biological systems using engineering principles, quantitative models and molecular tools.
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Epigenetic Regulation
Heritable or persistent control of gene activity mediated by chromatin state without changing DNA sequence.
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Single-Cell RNA Sequencing
Methods that measure transcript abundance in individual cells to resolve heterogeneous biological populations.
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Messenger RNA Vaccines
Vaccines that deliver temporary genetic instructions so cells produce an antigen and train adaptive immunity.
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Protein Folding
The process by which an amino-acid chain acquires the three-dimensional structure needed for biological function.
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CRISPR-Cas9 Gene Editing
A programmable molecular system that can cut DNA near a sequence selected by a guide RNA.
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