CAR T-Cell Therapy
Cell therapy in which a patient's or donor's T cells are engineered with a synthetic receptor that recognises a selected disease antigen.
SCIENDIA Knowledge Desk
Read article
Collaborative knowledge
Sciendia Wiki
A living academic reference written, refined and transparently versioned by the Sciendia community.
31published pages
Sign in to contribute
Collaborative knowledgeSearch
31 results Page 1/2
Wiki pages are public to read. Every signed-in member can create and improve them.
Clear search
Microbial Synthetic Communities
Designed groups of microbial species used to study and engineer ecological interactions with controlled membership and function.
SCIENDIA Knowledge Desk
Read article
Chromatin Architecture
The three-dimensional organisation of DNA, histones and regulatory complexes that helps control genome activity inside the nucleus.
SCIENDIA Knowledge Desk
Read article
Immunometabolism
The reciprocal control between cellular metabolic pathways and the activation, differentiation and function of immune cells.
SCIENDIA Knowledge Desk
Read article
Protein Language Models
Machine-learning models that learn statistical representations of amino-acid sequences for prediction and molecular design.
SCIENDIA Knowledge Desk
Read article
Ocean Acidification
The long-term shift in seawater carbonate chemistry caused primarily by ocean uptake of anthropogenic carbon dioxide.
SCIENDIA Knowledge Desk
Read article
Paleogenomics
The reconstruction and analysis of genomes from ancient biological remains to study populations, evolution and disease through time.
SCIENDIA Knowledge Desk
Read article
mRNA Therapeutics
Medicines that deliver engineered messenger RNA so cells transiently produce a therapeutic protein or antigen.
SCIENDIA Knowledge Desk
Read article
Autophagy
Cellular pathways that deliver cytoplasmic material to lysosomes or vacuoles for degradation, quality control and recycling.
SCIENDIA Knowledge Desk
Read article
Planetary Habitability
The capacity of a planetary environment to sustain conditions compatible with life over relevant places and times.
SCIENDIA Knowledge Desk
Read article
Bioprinting
Layer-by-layer fabrication of living tissue constructs using cells, biomaterials and spatially controlled deposition.
SCIENDIA Knowledge Desk
Read article
Spatial Transcriptomics
Methods that measure gene expression while preserving the locations and neighbourhoods of cells within tissue.
SCIENDIA Knowledge Desk
Read article
Viral Evolution
The change of viral populations through mutation, selection, recombination, migration and genetic drift across hosts and time.
SCIENDIA Knowledge Desk
Read article
Circadian Rhythms
Endogenous biological cycles near twenty-four hours that coordinate physiology and behaviour with environmental time.
SCIENDIA Knowledge Desk
Read article
Coral Reef Resilience
The capacity of reef ecosystems to resist disturbance, recover structure and retain ecological function under environmental change.
SCIENDIA Knowledge Desk
Read article
Gene Regulatory Networks
Interacting genes, regulatory DNA and molecular factors that control when and where biological programmes are expressed.
SCIENDIA Knowledge Desk
Read article
Ribosome Translation
The molecular decoding of messenger RNA into an ordered amino-acid chain by ribosomes and transfer RNAs.
SCIENDIA Knowledge Desk
Read article
Organoids
Three-dimensional, self-organising cell cultures that reproduce selected structural and functional features of organs.
SCIENDIA Knowledge Desk
Read article
Computational Protein Design
The algorithmic creation of amino-acid sequences expected to fold into structures with specified biochemical functions.
SCIENDIA Knowledge Desk
Read article
Synthetic Biology
The design and construction of biological systems using engineering principles, quantitative models and molecular tools.
SCIENDIA Knowledge Desk
Read article
Microbiome Metagenomics
The culture-independent analysis of collective microbial genomes recovered from an environmental or host-associated sample.
SCIENDIA Knowledge Desk
Read article
Epigenetic Regulation
Heritable or persistent control of gene activity mediated by chromatin state without changing DNA sequence.
SCIENDIA Knowledge Desk
Read article
Single-Cell RNA Sequencing
Methods that measure transcript abundance in individual cells to resolve heterogeneous biological populations.
SCIENDIA Knowledge Desk
Read article
Exoplanet Detection
Methods for identifying and characterising planets orbiting stars beyond the Solar System.
SCIENDIA Knowledge Desk
Read article